PATIENTS + PROFITABILITY™ PHILOSOPHY

Patients + Profitability™: A Philosophy for Patient Access and Financial Performance..

A Philosophy. A Purpose.
A Better Way Forward.

Patients + Profitability™ is a commercialization philosophy that unites the patient journey and the commercial journey into one strategic framework. By understanding where patients are lost and where profitability leaks, organizations can make better decisions, improve outcomes, and create sustainable value for everyone.

Patients + Profitability™ philosophy uniting patient access and GTN strategy

Better Access. Better Outcomes. Better Business.

Every patient begins a journey toward therapy. Along the way, ten exits can pull them off course. At the same time, five layers of commercialization friction quietly erode profitability. Patients + Profitability™ brings both journeys together to create a complete commercialization ecosystem.

The 10 Exits of Therapy™ framework diagram
Every Prescription Begins a Journey

The 10 Exits of Therapy™

The 10 Exits of Therapy™ identifies the critical moments where patients may leave the treatment journey before therapy begins. It provides healthcare organizations with a common language for understanding patient barriers, improving access, and supporting better health outcomes.

Framework Overview
  • Diagnosis
  • Provider Access
  • Prescription Creation
  • Enrollment
  • Coverage
  • Authorization
  • Affordability
  • Fulfillment
  • Patient Engagement
  • Therapy Initiation
PATIENTS + PROFITABILITY™ PHILOSOPHY

What Is the Two Journeys™ Framework?

Every patient moves through two journeys at the same time. One is visible — the appointments, prescriptions, tests, and treatments that make up the practical path to therapy. The other is invisible — the fear, hope, uncertainty, and resilience a patient carries every step of the way, rarely captured in any report or metric. Patients + Profitability™ is built on the belief that these two journeys are inseparable: an organization that manages only the visible journey is missing half of what actually determines whether a patient reaches therapy at all.

THE PHILOSOPHY

Healthcare Has Never Been About One Journey.

For decades, patient access and commercial performance have been treated as separate objectives. Patients + Profitability™ challenges that thinking by showing these outcomes are fundamentally connected — and that success depends on understanding both.

Every patient begins a journey toward therapy. Every organization manages a journey toward profitability. Organizations that understand both create better access, better outcomes, and better business.

Patients + Profitability™ aligns Commercial, Market Access, Finance, Patient Services, Medical Affairs, Specialty Pharmacy, and Executive Leadership around one objective: improving the patient experience while creating sustainable organizational value.

01

Patients First

Every commercial decision influences a patient's ability to begin and continue therapy. Access is central to strategy.

02

Profitability With Purpose

Financial strategy should support long-term access and growth, not create unnecessary friction.

03

One Connected Ecosystem

Patients, providers, payers, pharmacies, manufacturers, finance, and market access are all one ecosystem.

01

Patients First

Every commercial decision influences a patient's ability to begin and continue therapy. Access is central to strategy.

02

Profitability With Purpose

Financial strategy should support long-term access and growth, not create unnecessary friction.

03

One Connected Ecosystem

Patients, providers, payers, pharmacies, manufacturers, finance, and market access are all one ecosystem.

01

Patients First

Every commercial decision influences a patient's ability to begin and continue therapy. Access is central to strategy.

02

Profitability With Purpose

Financial strategy should support long-term access and growth, not create unnecessary friction.

03

One Connected Ecosystem

Patients, providers, payers, pharmacies, manufacturers, finance, and market access are all one ecosystem.

Patients + Profitability™ Is More Than a Framework. It Is a New Way of Thinking About Healthcare Commercialization.

By bringing the patient journey and the commercial journey into one unified philosophy, organizations can align cross-functional teams, improve patient access, strengthen financial performance, and create sustainable value across the healthcare ecosystem.

WHY IT MATTERS

Why Leaders Are Adopting Patients + Profitability™

Leading pharmaceutical organizations recognize that patient access, commercialization, finance, market access, and GTN strategy are interconnected. Patients + Profitability™ provides a shared philosophy that aligns commercial decisions with both patient outcomes and financial performance.

Better Patient Access

Higher Commercial Performance

Stronger Financial Outcomes

Sustainable Innovation

FREQUENTLY ASKED QUESTIONS

Patients + Profitability™: Common Questions

Answers to the most common questions about the Patients + Profitability™ philosophy, the Two Journeys™ framework, and how patient access connects to gross-to-net (GTN) performance.

What is the Patients + Profitability™ philosophy?
Patients + Profitability™ is a commercialization philosophy created by Patrick R. Coyle that connects the patient journey with the commercial journey. It is built on the principle that improving patient access and reducing patient leakage is directly connected to reducing revenue leakage and strengthening gross-to-net (GTN) performance.
What is the Two Journeys™ framework?
Every patient moves through two journeys at the same time. One is visible — the appointments, prescriptions, tests, and treatments that make up the practical path to therapy. The other is invisible — the fear, hope, uncertainty, and resilience a patient carries every step of the way, rarely captured in any report or metric. Patients + Profitability™ is built on the belief that these two journeys are inseparable: an organization that manages only the visible journey is missing half of what actually determines whether a patient reaches therapy at all.
What is The 10 Exits of Therapy™?
The 10 Exits of Therapy™ identifies the critical moments where patients may leave the treatment journey before therapy begins, including diagnosis, provider access, prescription creation, enrollment, coverage, authorization, affordability, fulfillment, patient engagement, and therapy initiation.
What is The 5 Layers of GTN™?
The 5 Layers of GTN™ organizes gross-to-net (GTN) strategy into five connected layers: Clinical & Product, Access & Policy, Channel & Distribution, Affordability & Support, and Financial & Reporting—linking commercial decisions to financial outcomes.
How does patient access affect GTN and revenue performance?
When patients encounter delays to therapy, affordability barriers, coverage restrictions, or adherence challenges, manufacturers often experience lower utilization, weaker forecasting, reduced visibility, and lost profitability. Patients + Profitability™ treats patient access and GTN performance as one connected outcome.
Who created the Patients + Profitability™ philosophy?
The philosophy was created by Patrick R. Coyle, a Chief Financial Navigator and life sciences finance executive with 25+ years of experience in pharmaceutical finance, GTN strategy, and commercialization, including leadership roles at Eisai, Bayer, and IQVIA.
How does Patients + Profitability™ relate to NextGen GTN™?
Patients + Profitability™ is the guiding philosophy, while NextGen GTN™ is the operating framework built from it—applying the same patient-access-to-GTN thinking to practical gross-to-net strategy, forecasting, and commercial finance transformation.